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Jun 21, 2026
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Batch: BIL-SRM-01-2602Feb 4, 2026
Metabolic & Weight Loss$65.00
5-Amino-1MQ
NNMT inhibitor studied for boosting NAD+, mitochondrial function, and metabolic health.
$65.00
99.91% Purity Verified
Third-Party Tested by Verum Analytics
Batch: BIL-SRM-01-2602Feb 4, 2026
+99% Purity
Third-Party Tested
COA Available
21 sold in the last 24 hours
Order in 0h 0min for same-day shipping
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Albert's Verdict
5-Amino-1MQ selectively inhibits NNMT — an enzyme that's essentially a metabolic brake. Blocking it shifts the methionine cycle toward elevated SAM levels and NAD+ production. The fat cell differentiation data is genuinely interesting.
View COAArrives as lyophilized (powder) form
Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.
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Product Description
5-Amino-1MQ is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor that supports cellular NAD+ levels and mitochondrial function. Originally developed for metabolic research, it has become one of the most talked-about longevity compounds for its potential to enhance energy metabolism, improve insulin sensitivity, and support fat loss at the cellular level.
Unlike injectable peptides, 5-Amino-1MQ is orally bioavailable and typically dosed once daily, making it a convenient addition to longevity and body-composition research protocols. For research use only. Not for human or veterinary consumption.
Technical Specifications
- Molecular Formula
- C11H13N3O
- Molecular Weight
- 203.24 g/mol
Customer Reviews
Verified research purchases
5.0(6 reviews)
Rachel T.Verified
2 weeks agoLegit quality - verified myself
The purity checked out when I verified the COA on the lab's website. Shipped with ice packs and arrived in perfect condition. This is how every supplier should operate.
52 people found this helpful
Amanda S.Verified
3 weeks agoFast shipping, great packaging
Ordered on Monday, arrived Wednesday. Package was cold and properly sealed. The quality is exactly what I expected based on the reviews. Happy customer.
38 people found this helpful
Kevin B.Verified
1 month agoSwitched from another supplier
My previous supplier was inconsistent. BioInfinity's COAs are verifiable and the quality is consistent batch after batch. Worth the switch.
44 people found this helpful
Robert H.Verified
2 months agoBulk discount saved me money
The 15% off for 3+ units made this more affordable than other options. Quality is top notch and shipping was faster than expected.
29 people found this helpful
Lisa M.Verified
1 week agoFifth order and counting
Been a customer for over a year now. The quality and service have been consistently excellent every single time. My go-to source.
61 people found this helpful
Jennifer C.Verified
4 weeks agoCustomer service actually helps
Had questions about storage and they responded same day with helpful info. Nice to deal with a company that actually cares about their customers.
17 people found this helpful
Frequently Researched Together
Commonly studied alongside in laboratory settings
Bundle total (3 items):$132.00
Verified reviews — 5-Amino-1MQ
1 verified buyer
★★★★★
5.0 / 5Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.
Learn More About This Peptide
Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.
Research summary
5-Amino-1MQ — clinical & mechanistic profile
5-Amino-1MQ is a selective, membrane-permeable small-molecule NNMT inhibitor (EC50 ~2.3 µM in adipocytes) that blocks nicotinamide methylation to 1-MNA, preserving nicotinamide for NAD+ salvage, elevating NAD+ 1.2-1.6 fold, and activating Sirt1 for metabolic benefits including ~35% adipose reduction without appetite effects.
Research status
preclinical
Molecular weight
173.21 g/mol
Molecular formula
C10H11N2O
Studied applications
- •NNMT inhibition: selective competitive inhibition (EC50 ~2.3 µM) preserves nicotinamide for NAD+ synthesis
- •NAD+ elevation: increases cellular NAD+ 1.2-1.6 fold by shunting nicotinamide into salvage pathway
- •Anti-obesity effects: ~35% EWAT reduction, ~5.1% body weight loss in DIO mice without food intake changes
- •SAM preservation: prevents SAM depletion, maintaining methylation capacity for other cellular reactions
- •Metabolic reversal: reverses diet-induced insulin resistance via Sirt1-mediated glucose/fat metabolism
- •Muscle benefits: improved exercise capacity and reduced recovery time in aged mice via mitochondrial NAD+
Mechanisms of action
- •Competitive NNMT inhibition: binds catalytic pocket, blocks nicotinamide → 1-MNA conversion (EC50 ~2.3 µM)
- •NAD+ salvage preservation: nicotinamide enters NAMPT → NMN → NAD+ pathway instead of methylation
- •SAM conservation: prevents SAM consumption by NNMT, supporting other methylation-dependent reactions
- •Sirt1 activation cascade: elevated NAD+ activates sirtuins for metabolic regulation, mitochondrial biogenesis
- •Lipogenesis suppression: reduces fat synthesis markers in adipocytes, shrinks adipocyte size
- •Insulin sensitivity improvement: Sirt1-mediated enhancement of glucose homeostasis and fat oxidation
Research constraints & safety notes
- •Small molecule compound—NOT a peptide despite common categorization
- •Exclusively preclinical—no human clinical trials conducted
- •Mechanism validated only in cell culture and mouse models
- •Long-term effects of chronic NNMT inhibition unknown
- •Quality and purity of research compounds varies
Peer-reviewed references
- Neelakantan H, et al. — NNMT inhibitor structure and adipocyte effects (2018)PMID: 29373119View
- 5-Amino-1MQ anti-obesity effects in DIO mice (2021)PMID: 34373117View
- NNMT inhibition and metabolic regulation reviewPMID: 29295905View
- PMC12054684 — 5-Amino-1MQ NAD+ elevation and metabolic mechanisms
- PMC11226645 — NNMT inhibitors in metabolic disease research
For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.