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Batch: BIL-EPT10-01-2603Mar 7, 2026
Longevity$200.00
Epithalon (Epitalon)
AEDG tetrapeptide (Epitalon) — the most-researched telomerase activator for longevity and anti-aging.
$200.00
99.3% Purity Verified
Third-Party Tested by Verum Analytics
Batch: BIL-EPT10-01-2603Mar 7, 2026
+99% Purity
Third-Party Tested
COA Available
21 sold in the last 24 hours
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Albert's Verdict
Epithalon's telomerase activation data is what puts it in a category of its own for cellular-aging research. The pineal gland regulation angle adds another layer — this tetrapeptide has more research depth than most compounds three times its size.
View COAArrives as lyophilized (powder) form
Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.
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Product Description
Epithalon (Epitalon / AEDG) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Russian scientist Vladimir Khavinson and studied for over 35 years. It is the most-referenced peptide in telomere and longevity research, best known for activating telomerase and extending telomere length in human cell studies (from 2.4 kb to over 4 kb in some studies).
Beyond telomere extension, Epithalon has been researched for enhanced melatonin production, improved immune function, and lifespan extension (25–33% in animal models). A staple of any longevity/anti-aging research protocol. For research use only. Not for human or veterinary consumption.
Technical Specifications
- Molecular Formula
- C14H22N4O9
- Molecular Weight
- 390.35 g/mol
- Sequence
- Ala-Glu-Asp-Gly
Customer Reviews
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Frequently Researched Together
Commonly studied alongside in laboratory settings
Bundle total (3 items):$117.00
Research FAQ — Epithalon (Epitalon)
Frequently asked questions about this compound for laboratory researchers.
What is Epithalon?+
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally derived from the bovine pineal extract Epithalamin. Published research investigates its effects on telomerase activity, pineal-axis signaling, and aging-related models in rodents and cell culture.
Cited: PMID 17298874, PMID 11788859
What does Epithalon research literature describe regarding telomerase?+
The 2007 publication in Bull Exp Biol Med reports observed increases in telomerase activity in human somatic-cell research models exposed to Epithalon. Researchers should refer to the cited paper for methodology and limitations.
Cited: PMID 17298874
How is Epithalon dosed in published research?+
Animal and cell-culture studies cite a wide concentration range. Researchers should consult the cited literature and their IRB-approved protocol; BioInfinity does not provide human dosing guidance.
How is Epithalon stored?+
Lyophilized at −20 °C; reconstituted held at 2–8 °C and used within 30 days. Refer to COA.
Published research references
Peer-reviewed literature relevant to Epithalon (Epitalon) research. Linked PubMed IDs open the original source.
- [1]Epithalon and telomerase activity in human somatic cells — Bull Exp Biol Med (2007) · PMID 17298874
- [2]Effect of Epithalamin and Epithalon on cell proliferation and apoptosis — Bull Exp Biol Med (2002) · PMID 11788859
- [3]Peptide Epithalon and pineal gland function in aging research — Neuro Endocrinol Lett (2003) · PMID 15622116
BL
Reviewed by the BioInfinity Research Team
Content reviewed by our research and quality team — biochemistry-degreed reviewers working alongside our analytical lab partner (Janoshik Analytical). Every product page is cross-checked against the cited peer-reviewed literature and the current batch's third-party COA.
For laboratory research use only. Not for human or veterinary use. Content is informational and does not constitute medical advice.
Verified reviews — Epithalon (Epitalon)
1 verified buyer
★★★★★
5.0 / 5Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.
Learn More About This Peptide
Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.
Research summary
Epithalon (Epitalon) — clinical & mechanistic profile
Epithalon is a synthetic tetrapeptide (AEDG) that activates telomerase via hTERT upregulation. A September 2025 Biogerontology study confirmed dose-dependent telomere extension in normal epithelial, fibroblast, and cancer cell lines. Brunel University (2025) independently replicated telomere lengthening across cell types. Additional 2025 data shows it restores antioxidant genes (SOD2, catalase, HO-1) and prevents DNA hypomethylation in hyperglycemic retinal cells.
Research status
preclinical
Sequence
Ala-Glu-Asp-Gly
Molecular weight
390.35 Da
Molecular formula
C14H22N4O9
Studied applications
- •Telomerase activation: upregulates hTERT mRNA, activating telomerase during G1 cell cycle phase via TRAP protocol confirmation
- •Telomere elongation: extends telomeres approximately 33.3% in somatic cells, increases proliferative potential beyond Hayflick limit
- •Cell lifespan extension: treated fetal fibroblasts reached 44+ passages vs. 34 for controls
- •Histone H1 binding: binds H1.3 and H1.6 variants, potentially triggering ALT pathways via H19 derepression
- •Anti-tumor effects: reduces spontaneous tumors and metastases in mice; inhibits MMP9 in aging skin fibroblasts
Mechanisms of action
- •hTERT upregulation: increases telomerase catalytic subunit mRNA expression primarily during G1 cell cycle phase
- •Chromatin modification: enters cell nuclei, binds promoter regions (ATTTC motifs) for epigenetic activation
- •Histone H1 binding: binds H1.3 and H1.6 variants, potentially inhibiting telomere stability proteins
- •Cancer cell selectivity: in telomerase-positive cancer cells, may trigger ALT pathway via H19 derepression rather than direct telomerase activation
- •Pineal gland modulation: influences melatonin synthesis pathways; derived from epithalamin (bovine pineal extract)
- •Heterochromatin effects: causes heterochromatin decondensation in elderly lymphocytes
Research constraints & safety notes
- •Most research originates from a limited number of research groups (primarily Russian)
- •Limited independent replication in Western research institutions
- •No FDA-approved human applications or completed Phase 3 trials
- •Telomerase activation in humans not confirmed in rigorous clinical trials
- •Long-term safety of telomerase activation uncertain (theoretical cancer concerns)
Peer-reviewed references
- Khavinson VK — Epithalamin telomerase activation research (2003)PMID: 12937225View
- Khavinson VK — Peptide bioregulation of aging (2003)PMID: 14501183View
- Anisimov VN — Peptide geroprotector studiesPMID: 16706657View
- Telomere elongation in human somatic cellsPMID: 11524632View
- PMC12411320 — Epithalon histone H1 binding and ALT pathway mechanisms (2024)
For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.