Suzanne R.Verified buyer
Jun 13, 2026
★★★★★
Purity great, fast shipping, great price!
Wonderful first time experience with this product.
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99.84% Purity Verified
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Batch: BIL-SEMAX-01-2602Feb 19, 2026
Cognitive & Nootropic$60.00
Semax
Synthetic ACTH-derived nootropic — increases BDNF, sharpens focus, and supports neuroprotection.
$60.00
99.84% Purity Verified
Third-Party Tested by Verum Analytics
Batch: BIL-SEMAX-01-2602Feb 19, 2026
+99% Purity
Third-Party Tested
COA Available
26 sold in the last 24 hours
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Albert's Verdict
Semax is one of the few peptides with reproducible BDNF and NGF elevation data in both rodent and primate models. The ACTH-derived structure gives it a unique CNS penetration profile — I keep this one on my active research list.
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Arrives as lyophilized (powder) form
Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.
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Product Description
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10, extensively studied for nootropic, neuroprotective, and neurorestorative effects. Originally developed in Russia for stroke recovery, it delivers rapidly to the brain and increases BDNF (Brain-Derived Neurotrophic Factor) levels via the CREB pathway while modulating dopamine and serotonin systems.
Recent 2024–2025 research has documented efficacy in Alzheimer's disease models (reducing amyloid inclusions and improving cognitive function), and emerging applications in ADHD, focus, memory, and neurodegenerative conditions. A cornerstone of cognitive-enhancement research. For research use only. Not for human or veterinary consumption.
Customer Reviews
Verified research purchases
5.0(7 reviews)
Nathan W.Verified
2 weeks agoHigh quality product
The purity is exactly what they claim. I verified the COA on the lab's website and it checked out. Fast shipping too.
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Rachel T.Verified
1 month agoConsistent quality every time
I've ordered multiple times and the quality is always the same. That consistency is important to me. Great supplier.
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Chris B.Verified
3 weeks agoExcellent product
Clean product, proper packaging, fast delivery. Everything you want from a supplier. Will definitely order again.
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Mark D.Verified
6 weeks agoProfessional from start to finish
From order to delivery, everything was handled professionally. The product arrived properly packaged with all documentation included.
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1 week agoTrusted source
Quality is non-negotiable for me and BioInfinity delivers. The verifiable COA and third-party testing give me confidence.
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Linda K.Verified
4 weeks agoVerifiable testing
The independent lab verification from Verum Analytics is a big plus. I verified the COA myself and it checked out. That transparency matters.
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Ryan P.Verified
2 months agoTop quality product
The purity is real - you can verify it yourself. Very few suppliers offer this level of transparency and quality.
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Frequently Researched Together
Commonly studied alongside in laboratory settings
Bundle total (3 items):$370.00
Verified reviews — Semax
1 verified buyer
★★★★★
5.0 / 5Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.
Learn More About This Peptide
Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.
Research summary
Semax — clinical & mechanistic profile
Semax is a synthetic heptapeptide analog of ACTH(4-10) that enhances BDNF and NGF expression, modulates dopaminergic, serotonergic, and cholinergic systems, and demonstrates neuroprotective effects through inhibition of nitric oxide synthesis, improved cerebral blood flow, and anti-inflammatory gene modulation in stroke research.
Research status
mixed
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Molecular weight
813.93 g/mol
Molecular formula
C37H51N9O10S
Studied applications
- •BDNF upregulation: intranasal administration increases BDNF levels in rat basal forebrain within 3 hours, supporting neuronal survival and synaptic plasticity
- •Neuroprotection in ischemia: inhibits nitric oxide synthesis, improves cerebral blood flow and oxygen delivery, reduces neuroinflammation
- •Neurotransmitter modulation: enhances dopaminergic (motivation/executive function), serotonergic (mood), and cholinergic (memory/attention) systems
- •Vascular effects: causes capillary bore extension within 15 minutes, alters genes promoting artery vasodilation within 3 hours of ischemic injury
- •Anti-amyloid properties: shows anti-aggregation properties against amyloid-beta, inhibiting fiber formation in presence of copper ions
Mechanisms of action
- •BDNF/NGF pathway: rapidly upregulates BDNF and NGF expression supporting neuronal survival and neurogenesis
- •Neurotransmitter enhancement: modulates dopaminergic (motivation), serotonergic (mood), and cholinergic (memory) activity
- •Melanocortin interactions: may antagonize α-MSH at MC4/MC5 receptors through specific, reversible, calcium-dependent membrane binding
- •Anti-inflammatory signaling: inhibits nitric oxide synthesis, reduces neuroinflammation by modulating inflammatory response genes
- •Vascular enhancement: improves cerebral blood flow, causes rapid vasodilation with capillary extension within 15 minutes
- •Blood-brain barrier penetration: modified structure with Pro-Gly-Pro enables efficient CNS delivery via intranasal route
Research constraints & safety notes
- •Approved only in Russia—not FDA approved or available by prescription in Western countries
- •Most research originates from Russian institutions with limited Western replication
- •Short half-life requires frequent administration or intranasal delivery for CNS effects
- •No completed Western clinical trials meeting FDA/EMA standards
- •Effects in Western populations and with Western medications largely unstudied
Peer-reviewed references
- Semax neuroprotective mechanisms in ischemia modelsPMID: 18076762View
- Semax BDNF and neurotrophic effects researchPMID: 26048037View
- Semax gene expression and anti-inflammatory effectsPMID: 27333909View
- Semax cognitive enhancement studiesPMID: 24292880View
- PMC3987924 — Semax gene expression in focal ischemia models
For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.