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Jun 8, 2026
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99.85% Purity Verified
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Batch: BIL-BATCH-01-2602Mar 2, 2026
Recovery & Repair$55.00
TB-500
Thymosin Beta-4 fragment — systemic tissue repair, cell migration, and full-body recovery peptide.
$55.00
99.85% Purity Verified
Third-Party Tested by Verum Analytics
Batch: BIL-BATCH-01-2602Mar 2, 2026
+99% Purity
Third-Party Tested
COA Available
29 sold in the last 24 hours
Order in 0h 0min for same-day shipping
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Albert's Verdict
Thymosin Beta-4's actin-binding mechanism is what makes it exceptional — it drives how tissue reorganizes in wound-model research. The migration data on endothelial cells is some of the most consistent I've reviewed.
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Arrives as lyophilized (powder) form
Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.
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Product Description
TB-500 is a synthetic 7-amino-acid fragment (Ac-LKKTETQ) corresponding to the active actin-binding region of Thymosin Beta-4 (Tβ4), a protein that plays a central role in cell migration, tissue repair, and angiogenesis. Compared to the parent peptide, TB-500 is more stable and more practical for research use.
Studied for accelerated healing of muscles, tendons, ligaments, and organs. Unlike locally-acting peptides such as BPC-157, TB-500 acts systemically — delivering full-body regenerative support. Frequently stacked with BPC-157 for the most-referenced recovery and tissue-repair protocol in peptide research. For research use only. Not for human or veterinary consumption.
Technical Specifications
- Molecular Formula
- C212H350N56O78S
- Molecular Weight
- 4963.5 g/mol
- Sequence
- Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
About TB-500
TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring 43-amino acid peptide found in high concentrations in blood platelets, wound fluid, and other tissues. Thymosin Beta-4 was originally isolated from thymus extracts in the 1960s and has since been identified as a major actin-sequestering protein with significant roles in cell migration, differentiation, and cellular pathway. TB-500 represents a truncated, active region of the full Thymosin Beta-4 molecule, making it more practical for research applications while retaining the key biological activity associated with the parent molecule.
Mechanism of Action
TB-500's biological effects stem from several well-characterized mechanisms that have been studied extensively in laboratory and preclinical settings:
Actin Sequestration: TB-500's primary function involves binding to G-actin (monomeric actin), preventing its polymerization into F-actin filaments. This regulation of actin dynamics is crucial for cell motility and morphological changes during cellular pathway.
Cell Migration Promotion: By modulating the actin cytoskeleton, TB-500 promotes cell migration—a critical process in wound-model research, angiogenesis, and cellular-pathway research. Research shows enhanced migration of endothelial cells, keratinocytes, and other cell types.
Angiogenesis Stimulation: Studies demonstrate TB-500's ability to promote new blood vessel formation. This involves upregulation of VEGF and other angiogenic factors, along with direct effects on endothelial cell proliferation and migration.
Inflammatory Pathway Research: Research indicates TB-500 may modulate cytokine expression and inflammatory cell activity in laboratory studies. Studies show altered expression of inflammatory markers in various experimental models.
Stem Cell Recruitment: Some research suggests TB-500 may influence the mobilization and differentiation of stem and progenitor cells, potentially contributing to its observed cellular-pathway effects.
Research Highlights
Cardiac Research
TB-500/Thymosin Beta-4 has been extensively studied in cardiac research. Studies in animal models of myocardial infarction have shown reduced scar formation, improved cardiac function, and enhanced survival of cardiomyocytes. Clinical trials have explored its potential in cardiac cellular-pathway research following heart attack.
Corneal Healing Studies
Significant research has focused on TB-500's effects on corneal healing. Studies demonstrate accelerated corneal wound closure, reduced inflammation, and improved outcomes in various corneal injury models. This research led to clinical development of Thymosin Beta-4-based eye drops.
Dermal Cellular Research
Research has examined TB-500's effects on skin wounds, including burns, incisions, and chronic wounds. Studies report accelerated wound closure, enhanced epithelialization, improved collagen organization, and reduced scarring in various experimental models.
Musculoskeletal Research
Preclinical studies have investigated TB-500's effects on muscle, tendon, and ligament injuries. Research shows potential benefits for muscle strain recovery, tendon healing, and joint health, with observations of reduced inflammation and accelerated cellular pathway.
Product Specifications
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molecular Weight | 4963.44 g/mol |
| Sequence | Ac-SDKPDMAEIIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES (43 AA) |
| Purity | ≥99% (HPLC verified) |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Solubility | Soluble in water, bacteriostatic water |
| Storage | -20°C (lyophilized), 2-8°C (reconstituted) |
Research Usage Guidelines
Reconstitution Protocol
- 1Allow vial to reach room temperature before reconstitution
- 2Use bacteriostatic water for multi-use applications
- 3Add solvent gently down the inside wall of the vial
- 4Allow to dissolve naturally or gently swirl—never shake
- 5Typical reconstitution: 2mL per 5mg vial yields 2.5mg/mL concentration
Storage Guidelines
- •Lyophilized TB-500: Store at -20°C for optimal long-term stability
- •Reconstituted: Refrigerate at 2-8°C, stable for 2-3 weeks
- •Protect from light exposure
- •Avoid multiple freeze-thaw cycles—aliquot for long-term storage
Frequently Asked Questions
TB-500 is a synthetic peptide based on Thymosin Beta-4, a naturally occurring protein involved in cell migration and cellular pathway research. It consists of 43 amino acids and has been studied for its potential healing and cellular-pathway properties.
Research References
- [1] Goldstein AL, et al. Thymosin beta4: a multi-functional regenerative peptide. Expert Opin Biol Ther. 2012;12(suppl 1):S37-S51.
- [2] Sosne G, et al. Thymosin beta 4 promotes corneal wound-model research and decreases inflammation in vivo following alkali injury. Exp Eye Res. 2002;74(2):293-299.
- [3] Bock-Marquette I, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-472.
- [4] Hinkel R, et al. Thymosin beta4: a key factor for protective effects of eEPCs in acute and chronic ischemia. Ann N Y Acad Sci. 2010;1194:105-111.
Learn More
Explore our comprehensive research guides for detailed information on peptide handling, storage, and research protocols.
Customer Reviews
Verified research purchases
5.0(7 reviews)
Mike T.Verified
2 weeks agoFinally found a quality source
Been searching for a reliable supplier for months. The purity is legit - you can verify it yourself on the lab's website. Shipped fast and arrived cold. Will definitely reorder.
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1 month agoThird order - never disappointed
This is my go-to source now. Consistent quality every time, and the customer service actually responds when you have questions. The quantity discounts are a nice bonus too.
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Jason R.Verified
3 weeks agoBest I've tried
After trying 3 different suppliers, this one stands out. The COA is verifiable, shipping is fast, and the product quality speaks for itself. Highly recommend.
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2 months agoSame-day shipping is clutch
Ordered before 2PM and it shipped the same day. Package arrived in perfect condition with ice packs still frozen. That's how it should be done.
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Chris M.Verified
1 week agoWorth every penny
You get what you pay for. The third-party testing and COA verification gives me confidence. Already placed my second order.
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6 weeks agoTransparency is refreshing
Love that I can verify the COA directly on Verum's website. The full analytical report with HPLC chromatogram checked out. This level of transparency is rare.
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1 month agoProfessional from start to finish
Proper packaging, cold shipping, and everything documented. You can tell they take quality seriously. Already recommended to friends.
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Frequently Researched Together
Commonly studied alongside in laboratory settings
Bundle total (3 items):$147.00
Research FAQ — TB-500
Frequently asked questions about this compound for laboratory researchers.
What is TB-500 and how is it studied?+
TB-500 is a synthetic fragment corresponding to amino acids 17–23 of the native protein Thymosin Beta-4. Published research investigates its role in actin sequestration, angiogenesis modulation, and migration of progenitor cells in tissue-injury models.
Cited: PMID 17192546, PMID 22737108
What concentrations are used in TB-500 research?+
Rodent and large-animal research papers cite a wide range, often 1–10 mg/kg administered intraperitoneally or subcutaneously. Researchers should follow their IRB protocol and the dosing reported in the cited literature.
Cited: PMID 22737108
How is TB-500 different from full-length Thymosin Beta-4?+
TB-500 represents an active fragment of the full 43-amino-acid Thymosin Beta-4 protein. Research suggests the fragment retains the actin-binding region thought to mediate several of TB-4's reported effects.
Cited: PMID 17192546
How should TB-500 be reconstituted and stored?+
Lyophilized TB-500 is typically reconstituted with bacteriostatic water at 1–5 mg/mL and stored at 2–8 °C after reconstitution. Lyophilized vials store at −20 °C. Refer to your laboratory's SOP and product COA.
Published research references
Peer-reviewed literature relevant to TB-500 research. Linked PubMed IDs open the original source.
- [1]Thymosin beta 4 and cardiac protection: implication in inflammation and fibrosis — Ann N Y Acad Sci (2012) · PMID 22737108
- [2]Thymosin beta-4: a multi-functional regenerative peptide — Expert Opin Biol Ther (2007) · PMID 17192546
- [3]Thymosin beta-4 and the anti-fibrotic effects on the heart — Ann N Y Acad Sci (2010) · PMID 21564349
BL
Reviewed by the BioInfinity Research Team
Content reviewed by our research and quality team — biochemistry-degreed reviewers working alongside our analytical lab partner (Janoshik Analytical). Every product page is cross-checked against the cited peer-reviewed literature and the current batch's third-party COA.
For laboratory research use only. Not for human or veterinary use. Content is informational and does not constitute medical advice.
Verified reviews — TB-500
1 verified buyer
★★★★★
5.0 / 5Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.
Learn More About This Peptide
Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.
Research summary
TB-500 (Thymosin Beta-4 Fragment) — clinical & mechanistic profile
TB-500 is a synthetic 7-amino-acid fragment from thymosin beta-4's actin-binding site. A Phase 1/2 trial launched February 2026 investigates its cardiovascular effects in adults with stable atherosclerotic disease. Phase 1 safety data in 84 healthy volunteers showed favorable tolerability. 2025 research reveals its wound-healing activity may stem from the metabolite Ac-LKKTE rather than the parent compound.
Research status
clinical investigational
Sequence
Ac-LKKTETQ (active fragment of 43-aa Tβ4)
Molecular weight
4963 Da (full Tβ4) / ~900 Da (TB-500 fragment)
Molecular formula
C212H350N56O78S (full Tβ4)
Studied applications
- •G-actin sequestration: forms 1:1 complex with G-actin, preventing F-actin assembly, modulating cytoskeletal dynamics for cell migration
- •ROCK1 downregulation: decreases ROCK1 protein levels particularly under hypoxia, reducing profibrotic signaling via MRTFA/SRF pathways
- •Wound healing: Phase 2 trials show 42% improvement in reepithelialization by day 4, 61% by day 7; thicker collagen, reduced scarring
- •Cardiac protection: post-MI trials with EPC transplantation showed improved walk time and cardiac function at 6 months; activates epicardial progenitors
- •Progenitor mobilization: enhances stem cell recruitment and differentiation; reactivates embryonic gene programs in cardiac tissue
Mechanisms of action
- •G-actin sequestration: binds G-actin 1:1, inhibits F-actin polymerization, modulates actin structures in hypoxic cardiac cells
- •ROCK1/MRTFA pathway: decreases ROCK1 protein, reduces profibrotic signaling via MRTFA/SRF in cardiac cells under hypoxia
- •Cell migration promotion: alters cytoskeletal dynamics to enhance fibroblast, stem cell, and progenitor movement to injury sites
- •Angiogenesis induction: promotes new vessel formation via endothelial proliferation; increases capillary density and capsulin+ progenitors
- •Anti-inflammatory/anti-fibrotic: reduces myofibroblast accumulation, modulates inflammatory markers, decreases scarring potential
- •Epicardial activation: reactivates embryonic gene programs, epicardial thickening, Wnt pathway modulation in cardiac models
Research constraints & safety notes
- •Not approved by FDA or any regulatory agency for human therapeutic use
- •Prohibited by WADA under S0 category (Non-Approved Substances) for athletic use
- •Human clinical data limited to Phase 2 trials for specific wound types
- •Most evidence derives from animal models rather than human subjects
- •Long-term safety data in humans is not established
Peer-reviewed references
- Goldstein AL, et al. — Thymosin beta-4 in wound repair (2008)PMID: 18492738View
- Bock-Marquette I, et al. — Cardiac repair mechanismsPMID: 22431019View
- Phase 2 clinical trial results for pressure/stasis ulcersPMID: 23050815View
- Sosne G, et al. — TB4 in corneal wound healingPMID: 16923388View
- Smart N, et al. — Cardiac progenitor cell activationPMID: 17641392View
For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.