## What KPV is
KPV is a synthetic tripeptide (C-terminal α-MSH fragment). KPV is the C-terminal tripeptide of α-MSH that exerts anti-inflammatory effects via PepT1 transport and NF-κB inhibition, independent of melanocortin receptors. Reduces disease activity in murine colitis by >50%, suppresses LPS-induced cytokines by 60% in macrophages, and shows direct antimicrobial activity against S. aureus and C. albicans while sparing mammalian cells. It has a molecular formula C16H30N4O4, mass 342.43 Da. Its published amino-acid sequence is Lys-Pro-Val. Common synonyms in the literature include α-MSH fragment, Alpha-MSH 11-13, and Lys-Pro-Val. This SKU is a co-formulated blend that also contains GHK-Cu in the same vial — for research groups that want to combine the two under a single reconstitution.
## What it's studied for
Investigation of KPV to date is primarily preclinical, with the majority of citations concentrated in animal models and in-vitro assays rather than randomized controlled human trials. Published work referencing KPV spans NF-κB inhibition studies: In vitro research in macrophages, intestinal epithelial cells, and other cell types demonstrates KPV suppresses NF-κB activation in response to LPS, IL-1β, or TNF-α stimulation. This reduces downstream transcription of inflammatory genes, Gut inflammation models: Studies in colonic inflammation models show KPV promotes mucosal healing, downregulates TNF-α expression, and protects against ulcerative damage when delivered to inflamed intestinal tissue, and IL-1 receptor antagonism research: KPV mimics the KPT loop of IL-1 receptor antagonist degradation products, binding IL-1RI to terminate IL-1β signaling. This represents a melanocortin receptor-independent anti-inflammatory mechanism. Proposed mechanisms in the literature include PepT1 intracellular uptake: transported via PepT1 (required for activity; blocking with Gly-Leu abolishes effects) and NF-κB pathway inhibition: inside cells, inhibits NF-κB activation via interactions with nuclear transport proteins (importins). None of this material describes therapeutic outcomes in humans, and BioInfinity does not sell, market, or provide dosing guidance for KPV outside laboratory research.
## Laboratory handling — storage and reconstitution
Lyophilized KPV arrives as a fluffy off-white solid inside a sealed sterile vial. Because it ships as a lyophilized peptide (342.43 Da), the powder is best stored between 2–8 °C prior to reconstitution and returned to −20 °C in aliquots for long-term storage post-reconstitution. Reconstitution is typically performed with bacteriostatic water (0.9 % benzyl alcohol preserved) rather than sterile water because the preservative extends solution stability once the vial has been punctured. Warming the reconstituted solution to room temperature before drawing helps redissolve any peptide that has settled against the vial wall. Avoid repeated freeze–thaw cycles: for peptides in this molecular-weight range (342.43 Da), freeze–thaw stress is one of the most common causes of loss-of-purity between batches.
## How this batch is verified
Every batch of KPV ships with a batch-specific Certificate of Analysis produced by an ISO-accredited third-party analytical laboratory. Reversed-phase HPLC confirms the assay against the expected 342.43 Da mass (C16H30N4O4); mass spectrometry validates the exact monoisotopic mass; endotoxin (LAL) testing confirms bacterial-contamination limits appropriate for laboratory research; and residual-solvent panels confirm the manufacturing pipeline. The lot number on the outer label matches the COA on the public /coa-library page — every purity claim is independently verifiable before you open the vial.
## Related research
For the full mechanistic profile, published references, and constraint notes on KPV, see the [KPV research page](/research/kpv). All references cited on that page are peer-reviewed primary literature.
**Research use only.** KLOW Blend is sold strictly for in-vitro and animal research. It is not a drug, food, supplement, or cosmetic and is not intended for human or veterinary consumption. No statements on this page describe or imply any therapeutic effect.
Researchers should refer to peer-reviewed publications for primary sources on this compound. KLOW Blend is sold strictly for laboratory research use and is not intended for human or veterinary use.
