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GHK-Cu - 50 mg
Recovery & Repair

GHK-Cu

Copper peptide GHK-Cu — the gold standard for collagen synthesis, skin regeneration, and anti-aging research.

$50.00
99.93% Purity Verified

Third-Party Tested by Verum Analytics

Batch: BIL-GHK-01-2602Feb 4, 2026
+99% Purity
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Albert - Chief Researcher

Albert's Verdict

GHK-Cu at ≥99% purity does something elegant — it upregulates over 30 genes associated with tissue remodeling while simultaneously downregulating inflammatory markers. The copper chelation is critical; purity here is non-negotiable.

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Arrives as lyophilized (powder) form

Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.

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Product Description

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring copper-binding tripeptide found in human plasma. Plasma levels naturally decline from ~200 ng/mL at age 20 to ~80 ng/mL by age 60, which correlates with visible signs of aging and slower wound healing.

Research shows GHK-Cu affects the expression of over 30% of human genes and drives collagen production, elastin synthesis, tissue regeneration, hair-follicle stimulation, anti-inflammatory effects, and systemic anti-aging benefits. Injectable GHK-Cu delivers systemic distribution ideal for full-body skin, hair, and tissue-regeneration research. For research use only. Not for human or veterinary consumption.

Technical Specifications

Molecular Formula
C14H23CuN6O4
Molecular Weight
403.92 g/mol
Sequence
Gly-His-Lys:Cu

Frequently Researched Together

Commonly studied alongside in laboratory settings

Bundle total (3 items):$127.00

Verified reviews — GHK-Cu

4 verified buyers

4.5 / 5
Michael B.Verified buyer
Jun 14, 2026
Not sure

After taking GHK-Cu at the recommended dosage for a couple of months, I honestly didn’t notice any significant difference overall. I didn’t experience any negative side effects or adverse reactions, which was a positive, but I also didn’t see or feel any noticeable improvements. Everyone’s experience may be different, but for me, the results were minimal, and I was left somewhat disappointed after using it consistently for several months.

Deborah R.Verified buyer
Jun 12, 2026
Best quality

Easy reconstitution, excellent quality and purity.

Nancy D.Verified buyer
Jun 11, 2026
GHK-CU

Great customer service, great product and speedy delivery!

Michael P.Verified buyer
Jun 11, 2026
Quality Product

I was skeptical about ordering online, but product shipped quickly, very well packaged, and the quality seems top tier. Communication was great. Will be using them again for future purchases.

Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.

Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.

Research summary

GHK-Cu — clinical & mechanistic profile

GHK-Cu is a naturally occurring copper-binding tripeptide that regulates over 4,000 genes involved in tissue repair, collagen synthesis, and anti-inflammatory responses. 2025-2026 research confirms it delivers bioavailable copper, resets cellular gene expression to a youthful state, reduces IL-6/TNF-alpha, supports DNA repair via 84 anti-cancer-related genes, and shows cumulative collagen remodeling with 3-6 months of use.

Research status

clinical investigational

Sequence

Gly-His-Lys

Molecular weight

340.38 Da (free peptide) / 401.93 Da (copper complex)

Molecular formula

C14H24N6O4Cu (copper complex)

Studied applications

  • Gene expression modulation: studied for effects on over 4,000 genes affecting regeneration and inflammation
  • Wound healing: investigated in dermal repair, with topical applications better characterized than systemic
  • Skin aging: researched for collagen/elastin synthesis and antioxidant effects
  • Tissue remodeling: examined for extracellular matrix restructuring and metalloproteinase modulation
  • Anti-inflammatory: studied for effects on inflammatory cytokine expression

Mechanisms of action

  • Copper delivery: forms stable complex with Cu²⁺ (binding constant log10 ≈ 16.44), delivering copper while silencing redox toxicity
  • Gene expression: upregulates regenerative genes (TGF-β pathway) and downregulates inflammatory genes (IL-6, fibrinogen)
  • Collagen/elastin synthesis: stimulates fibroblast production of collagen, glycosaminoglycans, elastin, and decorin
  • Metalloproteinase modulation: affects MMPs and TIMPs for extracellular matrix remodeling
  • Antioxidant defense: inhibits ferritin iron release and activates antioxidant enzymes (SOD, catalase)
  • SIRT1 interaction: directly binds SIRT1 protein, potentially affecting cellular aging pathways
Research constraints & safety notes
  • Topical applications far better studied than systemic/injectable use
  • Human data primarily observational or from cosmetic studies rather than controlled clinical trials
  • Not approved as a drug by FDA or other regulatory agencies
  • Effects require copper availability—chelators abolish activity
  • Skin penetration requires specific pH and formulation considerations

Peer-reviewed references

  1. Pickart L, Margolina A — GHK-Cu regenerative and protective actions review (2018)PMID: 29986520View
  2. Pickart L, et al. — GHK-Cu gene expression effectsPMID: 25815989View
  3. Wound healing and tissue remodeling mechanismsPMID: 22585374View
  4. GHK-Cu in skin aging and wound repair (2022)PMID: 35083444View
  5. Copper peptides and skin regenerationPMID: 22666519View

For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.