Research Peptide · US Supplier
Buy TB-500 in the USA
TB-500 (Thymosin Beta-4 fragment) supplied for laboratory research. ≥99% HPLC purity, batch-matched third-party COA, cold-chain packaging, and same-day shipping from Manhattan.
About This Compound
TB-500 is a synthetic peptide fragment corresponding to the active region of Thymosin Beta-4 (TB-4), a naturally occurring 43-amino-acid actin-sequestering protein first isolated from calf thymus tissue in the mid-1980s. The commercial "TB-500" sold as a research peptide is a shorter fragment (typically a 17-mer or the 4-mer LKKTETQ actin-binding motif) synthesized for laboratory investigation of actin dynamics, angiogenesis, and endothelial migration.
The compound has been extensively investigated in the preclinical and in-vitro literature for its role in G-actin sequestration, cell-migration models, angiogenesis assays, and endothelial-tube-formation studies. Because Thymosin Beta-4 itself is one of the most abundant intracellular proteins in mammalian cells, TB-500 is a widely referenced tool compound in actin-cytoskeleton research.
Every TB-500 lot supplied by BioInfinity is synthesized by SPPS (Fmoc), purified by preparative reverse-phase HPLC to ≥99% purity at 214 nm, and identity-confirmed by ESI mass spectrometry. Endotoxin content is verified below 0.5 EU/mg by LAL assay. Each batch is sent to Verum Analytics (Switzerland) for a matching third-party COA that ships with every order and is publicly verifiable in our /coa-library.
TB-500 is presented as a lyophilized (freeze-dried) white powder in a septum-sealed 2 mg, 5 mg, or 10 mg vial for reconstitution with bacteriostatic water. It is stable at 2–8 °C for normal-use timeframes and at −20 °C for long-term storage protected from light.
Quality Benchmarks
Every batch shipped from BioInfinity is verified against these specifications by an independent third-party lab before release.
- Purity
- ≥ 99% by reverse-phase HPLC
- Identity
- Confirmed by ESI-MS mass spectrometry
- Endotoxin
- < 0.5 EU/mg (LAL assay)
- Third-Party COA
- Verum Analytics (Switzerland) — batch-matched
- Origin
- Solid-phase peptide synthesis (SPPS), Fmoc chemistry
- Presentation
- Lyophilized white powder, septum-sealed vial
- Storage
- Refrigerate 2–8 °C; long-term −20 °C, protect from light
- Batch Traceability
- Every vial tied to a lot number & verification code
Research Applications in the Literature
Non-exhaustive list of subjects investigated in the published preclinical / in-vitro literature. Provided for research-context reference only — not a claim of efficacy.
- G-actin sequestration / actin-cytoskeleton dynamics
- Endothelial cell migration assays
- Angiogenesis / tube-formation in-vitro models
- Fibroblast wound-scratch-closure assays
- Cardiac muscle cell (cardiomyocyte) proliferation studies
- Corneal epithelial repair models
- Hair-follicle stem-cell literature
- Neurite-outgrowth preclinical models
Frequently Asked Questions
Where can I buy TB-500 in the USA?▾
BioInfinity is a US-based research peptide supplier shipping TB-500 same-day from our Manhattan facility. Every vial ships with a batch-matched third-party Certificate of Analysis (COA) and includes cold-chain packaging when the transit route requires it.
What purity is your TB-500?▾
Our TB-500 is ≥ 99% pure by reverse-phase HPLC, identity-confirmed by mass spectrometry, and endotoxin-tested via LAL assay. The exact assay values for the batch you receive are published on your product page and are also included as a printed COA in the shipment.
Do you provide a Certificate of Analysis (COA) with TB-500?▾
Yes. Every shipment includes a batch-matched COA from an independent third-party laboratory (Verum Analytics, Switzerland). You can also verify the batch online in our public COA library using the verification code printed on the vial label — no login required.
How is TB-500 shipped?▾
USPS Priority (2-3 business days) or UPS Ground (3-5 days). Cold-chain packaging with gel packs sized to the transit route. Discreet plain unbranded outer boxes — the label carries only the address and standard postal markings.
What payment methods can I use for TB-500?▾
Credit / debit card (Visa, Mastercard, Amex, Discover), Zelle, Venmo, Cash App, USDC stablecoin, and wire transfer for institutional orders. Zelle typically clears fastest and is the most common payment method our repeat customers use.
Is TB-500 FDA-approved or intended for human use?▾
No. TB-500 is not FDA-approved for any therapeutic indication. BioInfinity supplies TB-500 strictly for in-vitro laboratory research. It is not intended for human, veterinary, or in-vivo use of any kind.
How should I store TB-500 once it arrives?▾
The lyophilized (freeze-dried) powder is stable at 2–8 °C refrigeration for normal-use timeframes. For extended storage until the expiry date, store at −20 °C protected from light. Once reconstituted for bench work, refrigerate at 2–8 °C and use within 3–4 weeks per general peptide-handling literature.
Can I get a bulk / institutional discount on TB-500?▾
Yes. Professional accounts qualify for tiered volume discounts. Create a Professional account at /account, or e-mail [email protected] with your institution and PO details.
What is your return policy on TB-500?▾
Unopened, cold-chain-intact vials can be returned within 14 days of delivery for a refund minus return shipping. Opened vials are non-returnable due to the nature of the product. If a shipment arrives damaged or thawed, contact us within 48 hours for a free replacement.
How fast do orders for TB-500 ship?▾
Orders placed by 3:00 PM ET Monday–Friday ship same-day from Manhattan. Weekend orders ship the following Monday. You'll receive a tracking number by email the moment the label is scanned by USPS or UPS.
Do you ship TB-500 internationally?▾
We ship domestically within the 50 United States plus Puerto Rico and the US Virgin Islands. International shipments are evaluated case-by-case and require additional documentation — please contact [email protected] for a quote.
Where can I read your TB-500 COA?▾
Every batch's COA is browsable from our public /coa-library page. You can also click the "View COA" button on the TB-500 product page (/product/tb-500) or on the vial label itself, which carries a QR code that resolves to the batch's verification page.
What is the difference between TB-500 and Thymosin Beta-4?▾
Thymosin Beta-4 (TB-4) is the full-length 43-amino-acid protein. TB-500 is a shorter synthetic fragment corresponding to the active actin-binding region of TB-4. Both are used in preclinical actin-dynamics literature; TB-500 is preferred for research when the shorter sequence is sufficient.
What sizes does TB-500 come in?▾
2 mg, 5 mg, and 10 mg septum-sealed lyophilized vials. Bulk sizes for institutional research are available on request through [email protected].
Related Research Peptides
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Ready to Order?
Same-day shipping from our Manhattan facility. Third-party Certificate of Analysis included with every shipment.
All products sold by BioInfinity are supplied strictly for in-vitro laboratory research use only. They are not FDA-approved for any therapeutic indication and are not intended for human or veterinary use.