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GLP3-R - 5 mg
Metabolic & Weight Loss

GLP3-R

Triple GLP-1 / GIP / glucagon receptor agonist — the highest-recorded weight loss of any obesity peptide.

$85.00
99.48% Purity Verified

Third-Party Tested by Verum Analytics

Batch: BIL-RET-01-2602Mar 7, 2026
+99% Purity
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Albert - Chief Researcher

Albert's Verdict

GLP3-R activates all three incretin receptors simultaneously — the breadth of metabolic signaling here is unlike anything in a single-receptor agonist. This is the one I keep coming back to.

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✓ In stock - Ships same day

Arrives as lyophilized (powder) form

Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.

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Product Description

GLP3-R is a next-generation tri-agonist that activates three metabolic receptors simultaneously — GLP-1, GIP, and glucagon. The Phase III TRIUMPH-4 trial (2025) reported up to 28.7–29% weight loss at 68 weeks with the 9–12 mg dose, the highest recorded weight loss of any obesity peptide to date.

Beyond weight loss, GLP3-R research has demonstrated improved glycemic control, meaningful pain reduction in osteoarthritis patients (76% in one study), and broad metabolic benefits. Considered the first new obesity drug class in ~20 years and the most powerful metabolic research peptide currently available. For research use only. Not for human or veterinary consumption.

Technical Specifications

Molecular Formula
C237H382N66O70S
Molecular Weight
5414.91 g/mol
Sequence
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-Aib-Gln-Asp-Glu-Leu-Phe-Glu-Trp-Leu-Leu-Glu-Gln-Leu-Arg-NH2

Frequently Researched Together

Commonly studied alongside in laboratory settings

Bundle total (3 items):$162.00

Research FAQ — GLP3-R

Frequently asked questions about this compound for laboratory researchers.

What is Retatrutide / GLP-3-R?+
Retatrutide is an investigational triple-agonist research peptide that interacts with GLP-1, GIP, and glucagon receptors. Published Phase 2 trial data describe metabolic and body-composition effects under controlled clinical-research conditions.
How does Retatrutide differ from Semaglutide and Tirzepatide?+
Research literature characterizes Semaglutide as a single (GLP-1) agonist, Tirzepatide as a dual (GLP-1 + GIP) agonist, and Retatrutide as a triple (GLP-1 + GIP + glucagon) agonist. Published data on the additional glucagon-receptor activity suggest differentiated metabolic effects in clinical-research populations.
What dosing has been reported in Retatrutide clinical research?+
Phase 2 publications describe weekly subcutaneous administration of 1–12 mg in trial cohorts. Researchers should reference the cited NEJM publication and their IRB-approved protocols.
How is Retatrutide stored?+
Lyophilized Retatrutide should be stored at −20 °C protected from light. Reconstituted solution is typically held at 2–8 °C and used within 28 days. Refer to the product COA and your laboratory's SOP.

Published research references

Peer-reviewed literature relevant to GLP3-R research. Linked PubMed IDs open the original source.

  1. [1]Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial — N Engl J Med (2023) · PMID 37314979
  2. [2]Retatrutide: pharmacology, clinical trials, and mechanism of action — Diabetes Obes Metab (2024) · PMID 38866447
  3. [3]Retatrutide for type 2 diabetes: Phase 2 trial outcomes — Lancet (2023) · PMID 37322535
BL
Reviewed by the BioInfinity Research Team
Content reviewed by our research and quality team — biochemistry-degreed reviewers working alongside our analytical lab partner (Janoshik Analytical). Every product page is cross-checked against the cited peer-reviewed literature and the current batch's third-party COA.
For laboratory research use only. Not for human or veterinary use. Content is informational and does not constitute medical advice.

Verified reviews — GLP3-R

34 verified buyers

4.9 / 5
Nancy F.Verified buyer
Jun 22, 2026
Shipping

I received it faster than I expected and the purity was what it claimed on the site. Was impressed with the ordering process.

Xavier R.Verified buyer
Jun 21, 2026

Its the best that I used I love it and I’ll buy it again

Nicholas Z.Verified buyer
Jun 18, 2026
Great pure product

Works as it should. Results are incredible.

Peter S.Verified buyer
Jun 18, 2026
Just as promised and fast shipping

Great selection pricing , customer service. Quick responses and help with any questions you have

Jonathan F.Verified buyer
Jun 16, 2026
Excellent purity quick shipping

Purity excellent, great reconstitution, quick shipping, great product.

James S.Verified buyer
Jun 16, 2026

Good product

Brian H.Verified buyer
Jun 14, 2026
Purity and Strength

Great purity, shipping was seamless and fast, easy to reconstitute product, quality packaging and customer service answered my questions quickly, prior to ordering

Kristin M.Verified buyer
Jun 13, 2026
Fast shipping, excellent purity.

This batch is very pure and arrived fast. Will definitely order again.

Rogan K.Verified buyer
Jun 13, 2026
Very good product

Excellent product. Everything that I had expected.

James M.Verified buyer
Jun 13, 2026
Fast and as advertised

Shipping was fast, product was advertised. Very pleased with the company. Have ordered two times so far. Thank you

Tyler M.Verified buyer
Jun 13, 2026
Exactly as described

Zero complaints with my experience with Bioinfinity. I have ordered three different items from them so far and all 3 have shown up just as described and either on time or earlier than expected in well-built packaging. I will continue to place orders through these guys as I have been nothing but satisfied with their products and service.

Allen A.Verified buyer
Jun 13, 2026

Excellent Quality

Anne B.Verified buyer
Jun 12, 2026
Excellent shipping, easy reconstitution

Lyophilized for longer storage, purity documentation, reconstitute as needed. No shipping delays and very fast delivery.

Mike H.Verified buyer
Jun 12, 2026
Excellent product tests include endotoxins!

Worked as it should, weight is dropping and I feel great!

Tracey P.Verified buyer
Jun 12, 2026
Fast shipping

Need back water so have not yet started therapy

Matthew B.Verified buyer
Jun 12, 2026
Lifelong Customer

Bio Infinity has truly made me a lifelong customer. My order was received quickly and wrapped well so the vials were safe in transit. Also, GLP3-R quality is unmatched. It has stopped my snack cravings and allows me to feel full on a normal portion size of my meal. In doing that, the weight has begun to just shed off. Amazing product!

Enis Q.Verified buyer
Jun 12, 2026
Excellent purity and fast shipping

Quick to mix and already seeing results.

Debbie D.Verified buyer
Jun 12, 2026
Excellent, satisfied

Everyone’s experience may be different, but for me, this has been a helpful tool in my weight-loss journey when combined with healthy eating and regular exercise. I will continue this product to better my health.

Kristy F.Verified buyer
Jun 12, 2026
Excellent Product and Purity

This product has worked great. Shipping was fast, packaging is professional, and product seems pure.

Todd F.Verified buyer
Jun 11, 2026
Good product quality, good value, fast shipping

I seem to have a lesser appetite and overall satiety is better. Digestion feels improved and I feel more relaxed overall.

Michael S.Verified buyer
Jun 11, 2026
Good

Works well

Robin H.Verified buyer
Jun 11, 2026
Good

Works well

Gani B.Verified buyer
Jun 11, 2026
Working as described

Down 12 lbs in 3 weeks

James K.Verified buyer
Jun 11, 2026
Research is going very well

My guinea pig has lost about 25lbs in 5 weeks so far. .Will buy again

Cuauhtemoc S.Verified buyer
Jun 11, 2026
Delivered Awesome Results – Best Decision for Body Recomposition!

What really stood out was the great purity of the product. It was top-notch and clean, which I believe made the results feel more effective and consistent.

Stanley S.Verified buyer
Jun 11, 2026
Batch is good

No problem with the batch. Working as advertised. Disappointed that sight did not recommend BW though. Thx

Ralph J.Verified buyer
Jun 11, 2026
Top purity

Bioinfinity is second to none, top notch customer service, shipping , and purity.

Michael S.Verified buyer
Jun 11, 2026
Great product

Works well

Shannon M.Verified buyer
Jun 11, 2026
Great company

This company is great yo work with - delivery is fast and very helpful

Linette D.Verified buyer
Jun 11, 2026
Great Quality, Great Company!

GLP-3 doing its job! Great quality and effective in doing what it says. Love the protective packaging. Shipment was fast. Communication and customer service outstanding..

Sherry C.Verified buyer
Jun 11, 2026
Excellent product, easy purchase, fast shipping, reasonable prices

Excellent product, easy purchase, fast shipping, reasonable prices. Only peptide company I'll use

Lauren B.Verified buyer
Jun 11, 2026
Excellent purity and fast shipping

This product shipped quickly and arrived with no issues. It appears to be working, although waiting to adjust to it and get results. With a transition from a GLP-1 to GLP-3, it’s to be expected. This was my second time purchasing and will be purchasing again.

Jasmine M.Verified buyer
Jun 11, 2026
Excellent purity

Fast shipping

Daniel B.Verified buyer
Jun 11, 2026
Great product! Very satisfied

Excellent product and very easy to reconstitute! Shipping was super fast & the whole experience was great

Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.

Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.

Research summary

GLP3-R — clinical & mechanistic profile

GLP3-R (Retatrutide/LY3437943) is a first-in-class triple agonist targeting GIP, GLP-1, and glucagon receptors simultaneously. Phase 3 TRIUMPH-4 trial (2026) showed 28.7% weight loss at 12mg/68 weeks — the highest ever reported. Additional Phase 3 data shows A1C reductions of 1.7-2.0%, up to 100% liver fat reduction in MASLD, and 14 mmHg systolic BP reduction. FDA approval projected for 2027.

Research status

clinical investigational

Molecular weight

4624.2 g/mol

Studied applications

  • Triple receptor agonism: first compound to activate GIP, GLP-1, and glucagon receptors in a single molecule
  • Phase 2 results: achieved 24.2% mean weight loss at highest dose (12 mg) over 48 weeks—highest reported for any anti-obesity medication
  • Phase 3 trials: multiple ongoing studies including TRIUMPH program for obesity, T2D, CKD, osteoarthritis, and cardiovascular outcomes
  • Glucagon component: adds energy expenditure and hepatic fat reduction beyond dual agonists
  • No plateau observed: weight loss continued throughout 48-week Phase 2 study without leveling off

Mechanisms of action

  • GLP-1 receptor agonism: glucose-dependent insulin secretion, appetite suppression, delayed gastric emptying
  • GIP receptor agonism: enhanced insulin sensitivity, potentiation of GLP-1 effects, improved lipid handling
  • Glucagon receptor agonism: increased energy expenditure, enhanced hepatic fat oxidation, thermogenesis
  • Synergistic metabolic effects: the three pathways produce additive/synergistic weight loss beyond dual agonists
  • Potential NASH/MASH benefit: glucagon component may specifically target hepatic steatosis
Research constraints & safety notes
  • Investigational compound—NOT yet FDA approved for any indication
  • Phase 3 trials ongoing through 2025-2026 with results pending
  • Glucagon component requires careful glycemic management in T2D patients
  • Long-term safety data still being collected
  • Not available as approved medication; only in clinical trials or as research compound

Peer-reviewed references

  1. Jastreboff AM, et al. — Phase 2 obesity trial (NEJM 2023)PMID: 37351564View
  2. GLP3-R Phase 2 diabetes trial resultsPMID: 38587237View
  3. Triple agonist mechanism reviewPMID: 37840095View
  4. PMC12026077 — GLP3-R GLP-1/GIP/glucagon mechanism comprehensive review
  5. ADA 2024 — New glp3-r Phase 3 TRIUMPH program data presentations

For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.