I received it faster than I expected and the purity was what it claimed on the site. Was impressed with the ordering process.

Third-Party Tested by Verum Analytics
GLP3-R
Triple GLP-1 / GIP / glucagon receptor agonist — the highest-recorded weight loss of any obesity peptide.
Third-Party Tested by Verum Analytics

Albert's Verdict
GLP3-R activates all three incretin receptors simultaneously — the breadth of metabolic signaling here is unlike anything in a single-receptor agonist. This is the one I keep coming back to.
View COA✓ In stock - Ships same day
Arrives as lyophilized (powder) form
Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.
Product Description
GLP3-R is a next-generation tri-agonist that activates three metabolic receptors simultaneously — GLP-1, GIP, and glucagon. The Phase III TRIUMPH-4 trial (2025) reported up to 28.7–29% weight loss at 68 weeks with the 9–12 mg dose, the highest recorded weight loss of any obesity peptide to date.
Beyond weight loss, GLP3-R research has demonstrated improved glycemic control, meaningful pain reduction in osteoarthritis patients (76% in one study), and broad metabolic benefits. Considered the first new obesity drug class in ~20 years and the most powerful metabolic research peptide currently available. For research use only. Not for human or veterinary consumption.
Technical Specifications
- Molecular Formula
- C237H382N66O70S
- Molecular Weight
- 5414.91 g/mol
- Sequence
- His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-Aib-Gln-Asp-Glu-Leu-Phe-Glu-Trp-Leu-Leu-Glu-Gln-Leu-Arg-NH2
Frequently Researched Together
Commonly studied alongside in laboratory settings
Research FAQ — GLP3-R
Frequently asked questions about this compound for laboratory researchers.
What is Retatrutide / GLP-3-R?+
How does Retatrutide differ from Semaglutide and Tirzepatide?+
What dosing has been reported in Retatrutide clinical research?+
How is Retatrutide stored?+
Published research references
Peer-reviewed literature relevant to GLP3-R research. Linked PubMed IDs open the original source.
- [1]Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial — N Engl J Med (2023) · PMID 37314979
- [2]Retatrutide: pharmacology, clinical trials, and mechanism of action — Diabetes Obes Metab (2024) · PMID 38866447
- [3]Retatrutide for type 2 diabetes: Phase 2 trial outcomes — Lancet (2023) · PMID 37322535
Verified reviews — GLP3-R
34 verified buyers
Its the best that I used I love it and I’ll buy it again
Works as it should. Results are incredible.
Great selection pricing , customer service. Quick responses and help with any questions you have
Purity excellent, great reconstitution, quick shipping, great product.
Good product
Great purity, shipping was seamless and fast, easy to reconstitute product, quality packaging and customer service answered my questions quickly, prior to ordering
This batch is very pure and arrived fast. Will definitely order again.
Excellent product. Everything that I had expected.
Shipping was fast, product was advertised. Very pleased with the company. Have ordered two times so far. Thank you
Zero complaints with my experience with Bioinfinity. I have ordered three different items from them so far and all 3 have shown up just as described and either on time or earlier than expected in well-built packaging. I will continue to place orders through these guys as I have been nothing but satisfied with their products and service.
Excellent Quality
Lyophilized for longer storage, purity documentation, reconstitute as needed. No shipping delays and very fast delivery.
Worked as it should, weight is dropping and I feel great!
Need back water so have not yet started therapy
Bio Infinity has truly made me a lifelong customer. My order was received quickly and wrapped well so the vials were safe in transit. Also, GLP3-R quality is unmatched. It has stopped my snack cravings and allows me to feel full on a normal portion size of my meal. In doing that, the weight has begun to just shed off. Amazing product!
Quick to mix and already seeing results.
Everyone’s experience may be different, but for me, this has been a helpful tool in my weight-loss journey when combined with healthy eating and regular exercise. I will continue this product to better my health.
This product has worked great. Shipping was fast, packaging is professional, and product seems pure.
I seem to have a lesser appetite and overall satiety is better. Digestion feels improved and I feel more relaxed overall.
Works well
Works well
Down 12 lbs in 3 weeks
My guinea pig has lost about 25lbs in 5 weeks so far. .Will buy again
What really stood out was the great purity of the product. It was top-notch and clean, which I believe made the results feel more effective and consistent.
No problem with the batch. Working as advertised. Disappointed that sight did not recommend BW though. Thx
Bioinfinity is second to none, top notch customer service, shipping , and purity.
Works well
This company is great yo work with - delivery is fast and very helpful
GLP-3 doing its job! Great quality and effective in doing what it says. Love the protective packaging. Shipment was fast. Communication and customer service outstanding..
Excellent product, easy purchase, fast shipping, reasonable prices. Only peptide company I'll use
This product shipped quickly and arrived with no issues. It appears to be working, although waiting to adjust to it and get results. With a transition from a GLP-1 to GLP-3, it’s to be expected. This was my second time purchasing and will be purchasing again.
Fast shipping
Excellent product and very easy to reconstitute! Shipping was super fast & the whole experience was great
Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.
Learn More About This Peptide
Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.
GLP3-R — clinical & mechanistic profile
GLP3-R (Retatrutide/LY3437943) is a first-in-class triple agonist targeting GIP, GLP-1, and glucagon receptors simultaneously. Phase 3 TRIUMPH-4 trial (2026) showed 28.7% weight loss at 12mg/68 weeks — the highest ever reported. Additional Phase 3 data shows A1C reductions of 1.7-2.0%, up to 100% liver fat reduction in MASLD, and 14 mmHg systolic BP reduction. FDA approval projected for 2027.
Research status
clinical investigational
Molecular weight
4624.2 g/mol
Studied applications
- •Triple receptor agonism: first compound to activate GIP, GLP-1, and glucagon receptors in a single molecule
- •Phase 2 results: achieved 24.2% mean weight loss at highest dose (12 mg) over 48 weeks—highest reported for any anti-obesity medication
- •Phase 3 trials: multiple ongoing studies including TRIUMPH program for obesity, T2D, CKD, osteoarthritis, and cardiovascular outcomes
- •Glucagon component: adds energy expenditure and hepatic fat reduction beyond dual agonists
- •No plateau observed: weight loss continued throughout 48-week Phase 2 study without leveling off
Mechanisms of action
- •GLP-1 receptor agonism: glucose-dependent insulin secretion, appetite suppression, delayed gastric emptying
- •GIP receptor agonism: enhanced insulin sensitivity, potentiation of GLP-1 effects, improved lipid handling
- •Glucagon receptor agonism: increased energy expenditure, enhanced hepatic fat oxidation, thermogenesis
- •Synergistic metabolic effects: the three pathways produce additive/synergistic weight loss beyond dual agonists
- •Potential NASH/MASH benefit: glucagon component may specifically target hepatic steatosis
- •Investigational compound—NOT yet FDA approved for any indication
- •Phase 3 trials ongoing through 2025-2026 with results pending
- •Glucagon component requires careful glycemic management in T2D patients
- •Long-term safety data still being collected
- •Not available as approved medication; only in clinical trials or as research compound
Peer-reviewed references
- Jastreboff AM, et al. — Phase 2 obesity trial (NEJM 2023)PMID: 37351564View
- GLP3-R Phase 2 diabetes trial resultsPMID: 38587237View
- Triple agonist mechanism reviewPMID: 37840095View
- PMC12026077 — GLP3-R GLP-1/GIP/glucagon mechanism comprehensive review
- ADA 2024 — New glp3-r Phase 3 TRIUMPH program data presentations
For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.