Third-Party Tested by Verum Analytics
Mitochondrial-derived exercise-mimetic peptide — insulin sensitivity, fat oxidation, and longevity research.
Third-Party Tested by Verum Analytics
Albert's Verdict
MOTS-c is the only mitochondrial-derived peptide I know of that translocates to the nucleus under metabolic stress — it's essentially your mitochondria sending an SOS that triggers whole-body adaptation. The insulin sensitivity data at 12 weeks is hard to ignore.
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Arrives as lyophilized (powder) form
Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome (the mitochondrial open reading frame of the 12S rRNA type-c). It acts as a mitohormone, regulating metabolic homeostasis and behaving as a natural exercise-mimetic — enhancing glucose uptake, fat oxidation, and AMPK activation even in the absence of exercise.
Research has documented improved insulin sensitivity, enhanced glucose metabolism, and effects on pancreatic islet cell senescence. MOTS-c levels naturally decline with age (but remain stable in long-lived species like naked mole rats), making it a prime candidate in metabolic longevity research. For research use only. Not for human or veterinary consumption.
Commonly studied alongside in laboratory settings
4 verified buyers
The Mot-C lived up to my expectations and then some! There was a bit of a shipping mix up and I can’t say enough about the great and responsive customer service. The folks at Bioinfinity have my business!
Excellent Service
Top of the line company, product purity second to none.
As advertised, Bioinfinity lab is my go to source for all peptides. Always have been consistent in purity and fast shipping.
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Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene. 2025 studies show it restores cardiac mitochondrial OXPHOS respiration and reduces fasting glucose/hypertrophy in T2D rat models, protects against acute lung injury, and delays weight gain in high-fat diet models. Analog CB411 shows superior stability for obesity/NASH. Levels decline 21% in elderly vs young adults.
Research status
preclinical
Sequence
MRWQEMGYIFYPRKLR
Molecular weight
2174.64 Da
Molecular formula
C101H152N28O22S2
For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.